Killer T cells could ignite immune response against cancer: study

Research brings cancer-killing cells to bear against a certain type of colorectal cancer tumour

Killer T cells could ignite immune response against cancer: studyA University of Alberta researcher has discovered how two signalling molecules recruit immune cells known as killer T cells to a specific type of colon cancer with more favourable patient outcomes. The finding may represent a therapeutic strategy to target other types of cancers. Kristi Baker, assistant professor in the Department of Oncology, examined tumours…

Four U of A researchers named to Royal Society of Canada

Innovators in women and children’s health, water safety, nutrition and archeology join ranks

Four U of A researchers named to Royal Society of CanadaWhy some are more susceptible to cardiovascular disease than others, even when taking into account life-modifying factors like smoking and exercise, boils down to developmental aspects that start in the womb, according to a global authority on vascular pathophysiology in the pregnancy complication of pre-eclampsia. “It sets the stage,” said Sandra Davidge, Distinguished University Professor in…

Discovery may improve understanding of how breast cancer spreads

Blocking a process involving a protein called BAD might lead to an ability to stem cancer's spread

Discovery may improve understanding of how breast cancer spreadsA team of University of Alberta researchers has identified an unexpected role for a protein known as BAD in the ability of cells to migrate in the body – a finding that has promising implications for understanding how breast cancer spreads. BAD, short for “BCL2 associated agonist of cell death,” has many roles in the…

Physically fit breast cancer patients more likely to complete chemotherapy

Findings could help doctors plan and support treatment to give patients the best outcomes possible

Physically fit breast cancer patients more likely to complete chemotherapyBreast cancer patients who were in better physical condition completed more of their chemotherapy treatments, according to a University of Alberta study that gives physicians further guidance in individualizing treatments and preparing patients for the road ahead. “Clinicians often talk about patients being fit for chemotherapy, but no one ever had looked at actual physical fitness variables…

Common chemotherapy drug linked to hearing loss in children

Half of children with cancer being treated with cisplatin suffer irreversible hearing loss

Common chemotherapy drug linked to hearing loss in childrenA University of Alberta research lab has helped identify a genetic variant that increases the risk of hearing loss in children with cancer who are treated with the widely used drug cisplatin. Amit Bhavsar, assistant professor in the Department of Medical Microbiology & Immunology and Canada Research Chair in Functional Genomic Medicine, led the U…

Lean on family, community after heartbreaking losses

Januel Ibasco kept his goals in sight despite the deaths of his mother and grandmother, and was inspired to explore his Filipino roots

Lean on family, community after heartbreaking lossesThe traditional Indigenous game of Back Push sees two competitors seated on the ground back-to-back with their arms locked. The object is to stand up together but push your opponent out of a designated area. The goal of a children’s version of the contest is to simply communicate and lean on each other so that,…

Incidents of serious parasitic disease on the rise in Alberta

The province is now the North American hotspot for a rare, potentially fatal disease

Incidents of serious parasitic disease on the rise in AlbertaA rare parasitic infection imported from Europe continues to take root in Alberta. The province is now the North American hotspot for human alveolar echinococcosis (AE), which takes the form of a growth in the liver, causing serious and potentially deadly health complications. A recently published review of known AE cases in Alberta found 17 instances…

Next-generation genetic sequencing to detect pancreatic and biliary cancer

Nearly $1M awarded to seven new projects from U of A researchers focusing on cancer, pulmonary, diabetes and neurology research

Next-generation genetic sequencing to detect pancreatic and biliary cancerSeven new University of Alberta research projects focusing on cancer, pulmonary disease, diabetes and neurology are the latest recipients of funding from the 2020 Kaye Competition. The annual competition supports individuals and collaborative, interdisciplinary and multidisciplinary teams in the pursuit of research, innovation and quality-improvement programs and projects that seek to establish new approaches to patient…

Hearing loss caused by common childhood cancer drug targeted

Research may eliminate the toxic side-effect of cispaltin in childhood cancer survivors

Hearing loss caused by common childhood cancer drug targetedUniversity of Alberta scientists have identified a receptor in cells that could be key to preventing permanent hearing loss in childhood cancer survivors being treated with the drug cisplatin. The researchers believe that, by inhibiting the receptor, they may be able to eliminate toxic side-effects from the drug that cause the hearing loss. Cisplatin is…

Unique cardiac rehabilitation program gives cancer patients hope

Helps cancer patients who also face heart damage due to their treatment

Unique cardiac rehabilitation program gives cancer patients hopeAsk Paul Guenard how he’s doing, and he’ll tell you, “Not bad for a guy who’s supposed to be dead!” While he laughs as he says it, Guenard did indeed face death six years ago when he underwent a stem cell transplant to treat mantle cell lymphoma. Afterwards, he said, he felt so weak he…

Marker may predict response to cancer immunotherapy

Abundance of protein galectin-9 in cancer patients is associated with poor response to immunotherapy

Marker may predict response to cancer immunotherapyUniversity of Alberta researchers have uncovered a link between the expression of the protein galectin-9 (gal-9) and whether a cancer patient will benefit from immunotherapy. The discovery could help inform physicians about which patients will likely respond to immunotherapy and lead to better treatment options. Immunotherapy or biological therapy is the treatment of disease by…

3-D bioprinting successfully used to create nose cartilage

Searching for a better solution to a clinical problem facing many patients with skin cancer

A team of University of Alberta researchers has discovered a way to use 3-D bioprinting technology to create custom-shaped cartilage for use in surgical procedures. The work aims to make it easier for surgeons to safely restore the features of skin cancer patients living with nasal cartilage defects after surgery. The researchers used a specially…

Nanomedicine used to provide better outcomes during chemotherapy

Nanomedicine used to provide better outcomes during chemotherapyA University of Alberta researcher is using nanotechnology to improve the effectiveness of chemotherapy treatments for cancer patients and reduce their side effects. Afsaneh Lavasanifar is a professor in the University of Alberta’s Faculty of Pharmacy & Pharmaceutical Sciences and an adjunct professor in the Department of Chemical and Medical Engineering. Her lab develops precision health solutions through nanomedicine,…

Innovative cancer therapy uses immune system to attack tumours

Re-engineers your immune system to target and attack cancer growing in your body

Innovative cancer therapy uses immune system to attack tumoursImagine if you could re-engineer your immune system to target and attack cancer growing in your body. A new clinical trial led by a clinician researcher at the University of Alberta is doing just that. Michael Chu, an assistant professor of oncology in the Faculty of Medicine & Dentistry, is leading a project to manufacture and…

Muscle wasting syndrome cause of many cancer-related deaths

Project delves into how one growth hormone contributes to the problem and whether drugs can stop it

Muscle wasting syndrome cause of many cancer-related deathsResearchers are looking for ways to prevent or slow cachexia, a muscle-wasting syndrome thought to cause up to a third of the 80,000 deaths related to cancer every year in Canada. By understanding the role of activin A, a growth factor that contributes to muscle wasting, the team hopes their lab research will eventually help…
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